Neosporin (Pfizer)

Neosporin (Pfizer) - General Information

15 residue peptide isolated from Bacillus brevis. With alternating D and L amino acids

Pharmacology of Neosporin (Pfizer)

Gramicidin is particularly effective against gram-positive bacteria. Because the drug is highly hemolytic, it cannot be administered internally and so is used only on the skin as a lotion or ointment. It is used primarily in the treatment of infected surface wounds, and in eye, nose, and throat infections. It is normally given with two other antibiotics (neomycin and polymixin B) as an ophthalmic solution

Additional information about Neosporin (Pfizer)

Neosporin (Pfizer) Indication: For treatment of skin lesions, surface wounds and eye infections
Mechanism Of Action: Neosporin (Pfizer) binds to and inserts itself into bacterial membranes (with a strong preference to gram-positive cell membranes). This results in membrane disruption and permeabilization. This leads to (i) loss of intracellular solutes (e.g., K+ and amino acids); (ii) dissipation of the transmembrane potential; (iii) inhibition of respiration; (iv) a reduction in ATP pools; and (v) inhibition of DNA, RNA, and protein synthesis, which leads to cell death.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Gramicidin D
Synonyms: Neosporin
Drug Category: Anti-Infectives; Antibiotic Agents; Ophthalmic Antibiotic; Topical Antibiotic
Drug Type: Biotech; Approved

Other Brand Names containing Gramicidin D: Neosporin (Pfizer);
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Neosporin (Pfizer): Not Available
Chemical IUPAC Name: (2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[2-[[(2S)-2-formamido-3-methylbutanoyl]amino]acetyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-(2-hydroxyethylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-4-methylpentanamide
Chemical Formula: C99H140N20O17
Gramicidin D on Wikipedia: https://en.wikipedia.org/wiki/Gramicidin_D
Organisms Affected: Not Available